Monday, March 31, 2008

Antioxidants

The whole mangosteen fruit has been shown to contain powerful antioxidants—compounds that inhibit oxidation or reactions promoted by oxygen and peroxides. Antioxidants are highly regarded for their ability to protect the body from the deteriorating effects of free radicals.

Free Radicals

Omni-present in our food, air and environment, free radicals storm our bodies every day. It’s a simple fact. Free radicals (compounds that seek an electron in order to become atomically balanced) attack our cells, stealing electrons from any substance with which it comes in contact. By removing electrons from healthy compounds, free radicals inflict damage—often known as oxidation—which is irreversible.

Antioxidants Can Help

The good news—antioxidants, like the ones abundant in every mangosteen, preempt free-radical damage by donating the needed electron and balancing the substance, rendering the free radical harmless.

Read more...

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Sunday, March 23, 2008

Mangosteen Treatment for Cancer

Can you believe it?


Then How It Works?


Various studies have shown that xanthones in Mangosteen have properties such as:
· anti-tumor (shrinks tumors)
· anti-leukemia
· antifungal (critical for all cancer patients)
· antibacterial (to protect DNA)
· antioxidants (at least two dozen different kinds of xanthones are in the mangosteen fruit)
· ant proliferation
· Kills cancer cells and causes apoptosis (programmed cell death) for some types of cancer.



This is a pretty impressive list of cancer credentials!


Mangosteen Treatment


In keeping with the excellent anti-cancer properties of many kinds of fruits, especially grapes and berries, mangosteen can be added to this exclusive list.

The mangosteen fruit (Garcinia mangostana L.) is grown in most Tropical Countries. Most of the scientific research on this fruit involves about a half dozen of the two dozen known xanthones in this fruit. Most of the xanthones in Mangosteen have yet to be researched. Mangosteen has a wide range of benefits, perhaps most result from its xanthone phytoceuticals/antioxidants. However, mangosteen also contains: catechins, polyphenols, minerals and vitamins.

As an antioxidant, mangosteen is very high among plants:


"A new laboratory test known as ORAC (Oxygen Radical Absorbance Capacity) has also shown that an ounce of mangosteen juice has 20 to 30 times the ability to absorb free radicals than one ounce of most fruits and vegetables. The ORAC test is one of the most accurate ways to measure the ability of antioxidants in a certain substance to absorb free radicals. The higher the ORAC score, the better the food is for the body."

Here are some of the xanthones in mangosteen:
· alpha-Mangostin
· beta-Mangostin
· 3-Isomangostin
· Mangostanol
· Gertanin
· Garcinone A
· Garcinone B
· Garcinone C
· Garcinone D
· Garcinone E
· Maclurin

In terms of direct studies on cancer, the following quote is related to cancer:


"We found that antiproliferative effect of CME [crude methanolic extract] was associated with apoptosis on breast cancer cell line by determinations of morphological changes and oligonucleosomal DNA fragments. In addition, CME at various concentrations and incubation times were also found to inhibit ROS production. These investigations suggested that the methanolic extract from the pericarp [skin] of Garcinia mangostana had strong antiproliferation, potent antioxidation and induction of apoptosis. Thus, it indicates that this substance can show different activities and has potential for cancer chemoprevention which were dose dependent as well as exposure time dependent.


"Antiproliferation, antioxidation and induction of apoptosis by Garcinia mangostana (mangosteen) on SKBR3 human breast cancer cell line," by Moongkarndi P, Kosem N, Kaslungka S, Luanratana O, Pongpan N, Neungton N.



Below is another study:



"Our results have shown that one of the xanthone derivatives which could be identified as garcinone E has potent cytotoxic effect on all HCC cell lines as well as on other gastric and lung cancer cell lines included in the screen. We suggest that garcinone E may be potentially useful for the treatment of certain types of cancer."




Garcinone E, a Xanthone Derivative, has Potent Cytotoxic Effect Against Hepatocellular Carcinome Cell Lines" by Chi-Kuan Ho, Yu-Ling Huang and Chieh-Chih Chen



Some of the more impressive research on mangosteen involves leukemia:



"We examined the effects of six xanthones from the pericarps of mangosteen, Garcinia mangostana, on the cell growth inhibition of human leukemia cell line HL60. All xanthones displayed growth inhibitory effects. Among them, alpha-mangostin showed complete inhibition at 10 microM through the induction of apoptosis."




Induction of apoptosis by xanthones from mangosteen in human leukemia cell lines," by Matsumoto K, Akao Y, Kobayashi E, Ohguchi K, Ito T, Tanaka T, Iinuma M, Nozawa Y.


Some of the mangosteen scientific studies can be found at the web site below:



http://www.raysahelian.com/mangosteen.html

One of the nice things about mangosteen is not only that it tastes good, but is also anti-diarrhea.
Here is how to get totally unbiased information about Mangosteen (from Dr. Duke):


This is the world famous Dr. Duke's Agricultural Research Service:



Website:
http://www.ars-grin.gov/duke/
It is rare that I endorse a particular brand of a product, but in this case I do endorse XanGo because of their patented process, extensive research and good distribution channels.


Supercharging This Treatment


If you wish to use mangosteen juice as a treatment for cancer, you are strongly advised to read this article:
Using mangosteen juice in a 'juice fast' treatment



An alternative cancer treatment should be a complete treatment protocol. Do NOT forget to study the complete treatment protocol for Stage I, II and III cancer patients and the complete treatment protocol for Stage IV cancer patients:










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MRI finds breast cancer before it becomes dangerous

A study in the Lancet (vol. 370, 11 August 2007) could lead to a change of paradigm in the early diagnosis of breast cancer. It states that magnetic resonance imaging (MRI) is substantially more accurate than mammography in diagnosing very early stages of breast cancer . Up to now MRI was thought to be hardly suited for the detection of such 'ductal carcinoma in situ (DCIS) . Researchers at the University of Bonn have now come to a completely different conclusion. In the past five years they examined more than 7000 women with both methods. In a total of 167 women the doctors found early forms of breast cancer 152 (92 %) of these were found using MRT, 93 (56 %) with mammography. Read more...

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Breast Cancer More Aggressive Among Obese Women

PHILADELPHIA Women with breast cancer have more aggressive disease and lower survival rates if they are overweight or obese, according to findings published in the March 15 issue of Clinical Cancer Research, a journal of the American Association for Cancer Research.
The more obese a patient is, the more aggressive the disease, said Massimo Cristofanilli, MD, associate professor of medicine in the Department of Breast Medical Oncology at The University of Texas M.D. Anderson Cancer Center. We are learning that the fat tissue may increase inflammation that leads to more aggressive disease. Read more...


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Breast Cancer

Original Articles

Disease Site

Breast Disease

Risk of early recurrence among postmenopausal women with estrogen receptor-positive early breast cancer treated with adjuvant tamoxifen (p 1437-1444)Hagen Kennecke, Heather McArthur, Ivo A. Olivotto, Caroline Speers, Chris Bajdik, Stephen K. Chia, Susan Ellard, Brian Norris, Malcolm Hayes, Jeff Barnett, Karen A. GelmonPublished Online: Feb 19 2008 11:27AMDOI: 10.1002/cncr.23320

Women who were at risk of early breast cancer recurrence while they were receiving tamoxifen were identified in this population-based study of postmenopausal women with early breast cancer.
Link to Wiley InterScience:


Link to original web site :

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Cancer - Reaserch Articles

Research Article: Chemical constituents of the gentianaceae V: Tetraoxygenated xanthones of swertia chirata buch.-ham


S. Ghosal *, P. V. Sharma, R. K. Chaudhuri, S. K. Bhattacharya


Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi-5, India
*Correspondence to S. Ghosal, Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi-5, IndiaDepartment of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi-5, India
setDOI("ADOI=10.1002/jps.2600620614")


Swertia chirata Buch.-Ham. (Gentianaceae) - isolation, identification of nine tetraoxygenated xanthones • Xanthones, tetraoxygenated - isolation, identification from Swertia chirata Buch.-Ham. (Gentianaceae) • Medicinal plants - isolation, identification of tetraoxygenated xanthones from Swertia chirata Buch.-Ham


Nine tetraoxygenated xanthones [1,5,8-trihydroxy-3-methoxyxanthone (I), 1-hydroxy-3,5,8-trimethoxyxanthone (II), 1-hydroxy-3,7,8-trimethoxyxanthone (III), 1,8-dihydroxy-3,5-dimethoxyxanthone (IV), 1,8-dihydroxy-3,7-dimethoxyxanthone (V), 1,3,6,7-tetrahydroxyxanthone-C2-D-glucoside (mangiferin, VI), 1,3,8-trihydroxy-5-methoxyxanthone (VII), 1,3,5,8-tetrahydroxyxanthone (VIII), and 1,3,7,8-tetrahydroxyxanthone (IX)] were isolated from the roots and aerial parts of Swertia chirata Buch.-Ham. (Gentianaceae) collected from Nepal and India. The identity of the xanthones was established by direct comparison with reference materials in most cases, preparation of derivatives, and spectral evidence (UV, IR, proton magnetic resonance, and mass spectrometry). Among these xanthones, II was not encountered before in nature and VI was found for the first time in the genus swertia. The biogenetic significance of the co-occurrence of several tetraoxygenated xanthones, of varying oxygenation patterns, in absence of the standard 1,3,5- and 1,3,7-trioxygenated xanthones in S. chirata and in related species is appraised. In addition to the tetraoxygenated xanthones (I-IX), a number of heterosides, triterpenes, and monoterpene alkaloids were isolated from this plant. Preliminary pharmacological screening of the total xanthones of S. chirata indicated that the medicinal properties ascribed to the plant extracts were due to these constituents.
Link to Wiley InterScience Research Articles on Cancer


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Thursday, March 20, 2008

What is Cancer?

Cancer

Cancer is a group of
diseases in which cells are aggressive (grow and divide without respect to normal limits), invasive (invade and destroy adjacent tissues), and sometimes metastatic (spread to other locations in the body). Read more...

Classification & external resources

When normal cells are damaged beyond repair, they are eliminated by
apoptosis (A). Cancer cells avoid apoptosis and continue to multiply in an unregulated manner (B).
Source:
http://en.wikipedia.org/wiki/Cancer

"Coming Soon in the next post"

The Fundamental Question of Cellular Health: Where Does the Problem Originate in a Cell? by Matthias Rath, M.D.

Understand how disease spreads in the body


Cancer cells uses "biological weapons" to multiply inside an organ and then spread through the entire body (metastasis).





The web site below brings you to the Wiley Inter Science Journal. You can find a lot of information about cancer.
http://www3.interscience.wiley.com/journal/28741/home

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